Peptide Dose Tracker

Injection Site Reactions: What Labels Report

Your product's label prints its own rate for injection site reactions, and the numbers differ from one product to the next1234. Below are those rates and what labels say about rotating sites, each with its date.

What the labels report

For an injection site reaction, tirzepatide's Zepbound label, dated Aug 28, 2026, reports 6% to 8% on tirzepatide and 2% on placebo1. Each label reports in its own format. Read each figure with its own label, not as one rate across products.

Saxenda's label, dated Jun 15, 2026, gives 13.9% on Saxenda and 10.5% on placebo2. Victoza's label, dated Nov 17, 2025, says reactions were reported in about 2% of treated adults3.

Trulicity's label, dated Aug 10, 2026, reports 0.5% in treated adults and 0.0% with placebo4. Keep these figures apart from the side effect rates in the same labels.

Antibodies and reaction rates

On Sep 2, 2026, the Zepbound label reports 11.3% in people with anti-tirzepatide antibodies and 1% in people without1. The Mounjaro label of that date reports 4.6% versus 0.7% across 7 trials5. Keep that comparison apart from the main trial table.

What labels say about rotating sites

The Wegovy label, dated Jun 30, 2026, says to change, or rotate, your injection site with each injection and not to use the same site every time6. Ozempic's label, dated Jun 10, 2026, uses the same wording7. The body map and areas named in patient instructions shows where those areas are.

Saxenda's label says to rotate sites within the same region and names cutaneous amyloidosis2. Victoza uses the same wording3. On Sep 2, 2026, the Zepbound and Mounjaro Instructions for Use named lipodystrophy and localized cutaneous amyloidosis15.

For insulin, MedlinePlus (Jul 21, 2024) says to keep a chart of the places you used and not use the same place every time8. NIDDK says repeated insulin shots in one spot could harden tissue9. ADA calls site rotation necessary for insulin10.

Keep a site and reaction log

Use the side effect log, the GLP-1 tracker, or the peptide tracker to record site, date and reaction wording in one place. You can also Log this injection and note a reaction.

What this log does not say

This page does not label a reaction for you. For questions about your own skin, follow your label and ask your pharmacist or prescriber. Source updates are on the dated FDA alerts page.

FDA takes adverse event reports online or by form through MedWatch, at 1-800-FDA-108811. For emergencies, call 911.

Questions

Should you rotate semaglutide injection sites?

The Wegovy Medication Guide, dated Jun 30, 2026, says to rotate your injection site with each injection6. The Ozempic label says the same7. Your product's Instructions for Use and your prescriber name the areas.

When should I worry about an injection site reaction?

This page does not tell you when to worry. The Medication Guides say to talk to your healthcare provider about any side effect that bothers you or does not go away16. You can report to FDA through MedWatch11, and in an emergency, call 911.

Read this first. Information only, not medical advice. This site does not recommend amounts. Talk to your prescriber or pharmacist about your own situation. 18+. Questions about your medicine, symptoms or a reaction? Contact your clinician or pharmacist. In an emergency, call 911. Poison Help: 1-800-222-1222.

Editorial review against cited sources. Last checked Oct 12, 2026.

Sources

  1. DailyMed: Zepbound label (opens in a new tab), FDA-reviewed label posted on DailyMed (U.S. National Library of Medicine), labeler Eli Lilly and Company. SPL version 40, label effective 2026-08-28 (Prescribing Information revised 08/2026); DailyMed listing posted Sep 02, 2026.
  2. DailyMed: Saxenda label (opens in a new tab), FDA-reviewed label posted on DailyMed (U.S. National Library of Medicine), labeler Novo Nordisk. SPL version 22, label effective 2026-02-25 (Medication Guide revised 02/2026, Instructions for Use 06/2026); DailyMed listing posted Jun 15, 2026.
  3. DailyMed: Victoza label (opens in a new tab), FDA-reviewed label posted on DailyMed (U.S. National Library of Medicine), labeler Novo Nordisk. SPL version 31, label effective 2025-10-14 (Medication Guide revised 05/2025); DailyMed listing posted Nov 17, 2025.
  4. DailyMed: Trulicity label (opens in a new tab), FDA-reviewed label posted on DailyMed (U.S. National Library of Medicine), labeler Eli Lilly and Company. SPL version 62, label effective 2026-06-16 (Prescribing Information revised March 2026); DailyMed listing posted Aug 10, 2026.
  5. DailyMed: Mounjaro label (opens in a new tab), FDA-reviewed label posted on DailyMed (U.S. National Library of Medicine), labeler Eli Lilly and Company. SPL version 40, label effective 2026-08-27 (Prescribing Information revised August 2026); DailyMed listing posted Sep 02, 2026.
  6. DailyMed: Wegovy label (opens in a new tab), FDA-reviewed label posted on DailyMed (U.S. National Library of Medicine), labeler Novo Nordisk. SPL version 19, label effective 2026-06-18 (Medication Guide revised 06/2026); DailyMed listing posted Jun 30, 2026.
  7. DailyMed: Ozempic label (opens in a new tab), FDA-reviewed label posted on DailyMed (U.S. National Library of Medicine), labeler Novo Nordisk. SPL version 20, label effective 2026-06-01 (Prescribing Information revised June 2026); DailyMed listing posted Jun 10, 2026.
  8. MedlinePlus: Giving an insulin injection (opens in a new tab), MedlinePlus, U.S. National Library of Medicine (NIH). Reviewed 07/21/2024.
  9. NIDDK: Insulin, Medicines, & Other Diabetes Treatments (opens in a new tab), National Institute of Diabetes and Digestive and Kidney Diseases (NIH). Reviewed March 2022.
  10. ADA: Standards of Care in Diabetes 2026, section 9 (opens in a new tab), American Diabetes Association. January 2026.
  11. FDA: MedWatch adverse event reporting (opens in a new tab), U.S. Food and Drug Administration. Program page (no page date).