GLP-1 Side Effects in FDA Prescribing Information

How to read these tables

Seven labels feed these tables, each dated by its DailyMed listing:

• Wegovy, Jun 30, 2026¹
• Zepbound, Sep 02, 2026²
• Ozempic, Jun 10, 2026³
• Mounjaro, Sep 02, 2026⁴
• Saxenda, Jun 15, 2026⁵
• Victoza, Nov 17, 2025⁶
• Trulicity, Aug 10, 2026⁷

Each percentage you see is the share of trial participants who reported that reaction.

Some labels use a 2% cut-off and some use 5%, so the rows differ by product. Keep the cut-off with any number you copy.

The placebo column is the label's comparison group for that table. If a table shows trial arms with no mg in the row title, copy the arm wording as printed.

The labels say rates from one drug's trials cannot be directly compared with another's, because the trials differ^{1,2,3,4,5,6,7}. Read each product's table on its own, with its label version line.

Tables by product

Numbers are copied from each label's own table by script on Oct 12, 2026 (DailyMed SPL XML). Treated arms are shown as a range across the arms in the label, with no dose printed. Percentages are the share of trial participants who reported the reaction. Rates from one product's trials cannot be directly compared with another's.

Wegovy (injection)

Table 3, adults with obesity or overweight, weight reduction trials, adverse reactions at 2% or more and more than placebo; the 7.2 mg table and the tablet tables are not copied (the label also covers tablets). Label version 19, effective Jun 18, 2026. DailyMed label (opens in a new tab)

Zepbound

Table 1, adults with obesity or overweight, pool of Study 1 and 2, 2% or more and more than placebo; arms shown as a range. Label version 40, effective Aug 28, 2026. DailyMed label (opens in a new tab)

a Includes diarrhea, frequent bowel movements. b Includes constipation, feces hard. c Includes abdominal discomfort, abdominal pain, abdominal pain lower, abdominal pain upper, abdominal tenderness. d Includes multiple related adverse event terms, such as injection site bruising, injection site erythema, injection site pruritus, injection site pain, injection site rash, injection site reaction. e Includes asthenia, fatigue, lethargy, malaise. f Includes blood pressure decreased, hypotension, orthostatic hypotension.

Ozempic

Table 1, adults with type 2 diabetes, placebo-controlled trials, 5% or more; arms shown as a range. Label version 20, effective Jun 1, 2026. DailyMed label (opens in a new tab)

Mounjaro

Table 1, adults, pool of placebo-controlled trials, common adverse reactions not including hypoglycemia; arms shown as a range. Label version 40, effective Aug 27, 2026. DailyMed label (opens in a new tab)

Note: Percentages reflect the number of patients who reported at least 1 occurrence of the adverse reaction.

Saxenda

Table 2, adults, 2% or more and more than placebo (the pediatric Table 3 is not copied). Label version 22, effective Feb 25, 2026. DailyMed label (opens in a new tab)

Victoza

Table 1, adults with type 2 diabetes, 5% or more. Label version 31, effective Oct 14, 2025. DailyMed label (opens in a new tab)

Trulicity

Table 1, adults with type 2 diabetes, pool of placebo-controlled trials, 5% or more and more than placebo; arms shown as a range. Label version 62, effective Jun 16, 2026. DailyMed label (opens in a new tab)

a Includes diarrhea, fecal volume increased, frequent bowel movements. b Includes retching, vomiting, vomiting projectile. c Includes abdominal discomfort, abdominal pain, abdominal pain lower, abdominal pain upper, abdominal tenderness, gastrointestinal pain. d Includes fatigue, asthenia, malaise. Note: Percentages reflect the number of patients that reported at least 1 treatment-emergent occurrence of the adverse reaction.

What the labels say about timing

Some labels say when certain reactions were reported during the trial period. You'll find those sentences in how long side effects lasted in label trials.

Where to read more in the label

Each label links its Warnings and Precautions section and its Medication Guide. For newer updates, check the dated FDA alerts.

FDA takes adverse event reports through MedWatch, online or by form⁸. The Medication Guides for these products give 1-800-FDA-1088. Note the label section you read.

Log what you notice

Use the side effect log or the GLP-1 tracker for a dated list. You can also Note it in the side effect log.